Van Hentenryck’s research is mostly in infrastructure optimization, applying data science and optimization to challenging problems in transportationenergy systems, and disaster management. He is primarily focusing on the RITMO project in urban mobility and the Grid Research for Good (GRG) project in energy, although he is also passionate about computational social science. In the past, his research focused on optimization and the design and implementation of innovative optimization systems, including the CHIP programming system (a Cosytec product), the foundation of all modern constraint programming systems, the Numerica system, the optimization programming language OPL (now an IBM Product), and the programming language Comet (with Laurent Michel). Van Hentenryck has also worked on computational biology, numerical analysis, and programming languages, publishing in premier journals in these areas.